Our research findings have been published in academic journals both in Japan and abroad. (2011–2023)

At our company, we have been publishing the research results obtained through the development of cancer immunotherapies and molecular targeted drugs in multiple peer-reviewed academic journals. Below is a list of papers published since 2011.

Publication date	Thesis Title	Publication	Authors
2023.8	Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy	Cell Reports	Kodama M., Toyokawa G., Sugahara O., Sugiyama S., Haratake N., Yamada Y., Wada R., Takamori S., Shimokawa M., Takenaka T., Tagawa T., Kittaka H., Tsuruda T., Tanaka K., Komatsu Y., Nakata K., Imado Y., Yamazaki K., Okamoto I., Oda Y., Takahashi M., Izumi Y., Bamba T., Shimizu H., Yoshizumi T., Nakayama K.I.
2020.5	A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer	Nature Communications	Kodama M., Oshikawa K., Shimizu H., Yoshioka S., Takahashi M., Izumi Y., Bamba T., Tateishi C., Tomonaga T., Matsumoto M., Nakayama K.I.
2020.12	A second Warburg-like effect in cancer metabolism: The metabolic shift of glutamine-derived nitrogen: A shift in glutamine-derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer	BioEssays	Kodama M., Nakayama K.I.
2017.5	A large-scale targeted proteomics assay resource based on an in vitro human proteome	Nature Methods	Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K., Nakayama K.I.
2023.5	Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors	Cancer Research	Oka T., Higa T., Sugahara O., Koga D., Nakayama S., Nakayama K.I.
2022.5	Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium	Nature Communications	Higa T., Okita Y., Matsumoto A., Nakayama S., Oka T., Sugahara O., Koga D., Tateishi S., Nakatsumi H., Hosen N., Robine S., Taketo M.M., Sato T., Nakayama K.I.
2020.12	Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland	Cancer Research	Onoyama I., Nakayama S., Shimizu H., Nakayama K.I.
2017.7	Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells	Nature Communications	Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama K.I.
2015.5	Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells	Nature Neuroscience	Furutachi S., Miya H., Watanabe T., Kawai H., Yamasaki N., Harada Y., Imayoshi I., Nelson M., Nakayama K.I., Hirabayashi Y., Gotoh Y.
2013.5	Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence	Cancer Cell	Onoyama I., Naka K., Hirao A., Nakayama K.I.
2011.9	p57 is required for quiescence and maintenance of adult hematopoietic stem cells	Cell Stem Cell	Matsumoto A., Takeishi S., Kanie T., Susaki E., Onoyama I., Tateishi Y., Nakayama K., Nakayama K.I.